mmp-9/mmp-13 inhibitor i

MMP-9/MMP-13 Inhibitor I is a dual inhibitor of MMP-9 and MMP-13 with IC50 of 0.9 nM for both enzymes. It is over 20 times more selective for MMP-9/MMP-13 than for other MMPs.

MMP-9 Inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). MMP-9 Inhibitor I also decreases activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 Inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells at concentrations of 50 and 100 μM. MMP-9 Inhibitor I is therefore used in neuroinflammatory and extracellular matrix regulation research to investigate metalloproteinase selectivity, cytokine shedding pathways, and microglial activation responses in cellular inflammation models.