ml 204

ML204 hydrochloride (ML204 HCl) is a selective and potent TRPC4/TRPC5 channel antagonist that blocks TRPC4β currents activated by intracellular dialysis via μ-opioid receptor stimulation or guanosine 5'-3-O-(thio)trisphosphate (GTPgammaS).

ML204 is a novel potent antagonist that selectively modulates native TRPC4 C5 ion channels.

Tilapia piscidin 3, an antimicrobial peptide, exhibits antibacterial properties effective against both gram-positive and gram-negative bacteria. It has demonstrated minimum inhibitory concentrations (MICs) of 2.44 µg mL for V. vulnificus 204 and V. alginolyticus, 9.78 µg mL for S. agalactiae 819, 19.55 µg mL for E. faecalis BCRC 10066, and 0.61 µg mL for S. agalactiae BCRC 10787. Additionally, it presents hemolytic activity on fish red blood cells [1].