mitochondrial atp-sensitive potassium

Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.

Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.

P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6) (EC50: 45 nM fo

BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.

Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), as well as an effective mKATP channel agonist and cardioprotective agent [1].

Glibenclamide (Standard) is the analytical reference standard of Glibenclamide intended for research and quantitative applications, and as an orally active ATP-sensitive potassium channel inhibitor, Glibenclamide directly binds SUR1 subunits of KATP channels, inhibits P-glycoprotein and CFTR, alters mitochondrial membrane ion permeability, induces autophagy, and supports research in diabetes, obesity, and cellular bioenergetics.