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mglu8 receptor

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  • Inhibitors & Agonists
    3
    TargetMol | Inhibitors_Agonists
VU6005649
T133212137047-43-7
VU6005649 is an agonist of CNS penetrant mGlu7 8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
  • $37
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VU0361737
ML-128, VU 0361737
T67261161205-04-4
VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of the mGlu4 receptor with an EC50 of 240 nM for human receptors and 110 nM for rat receptors. It exhibits weak activity at mGlu5 and mGlu8 receptors and is inactive at mGlu1, mGlu2, mGlu3, mGlu6, and mGlu7 receptors. The compound can penetrate the CNS.
  • $39
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L-AP4 monohydrate
L-AP4 monohydrate
T371272247534-79-6
L-AP4 (L-APB) monohydrate is a potent and specific agonist for group III mGluRs, with EC50s of 0.13, 0.29, 1.0, and 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively [1][2].
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6-8 weeks
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