mgat2

MGAT2-IN-1 is an orally active monoacylglycerol acyltransferase (MGAT2)inhibitor (human and mouse MGAT2 with IC50 of 7.8 and 2.4 nM , respectively).

MGAT2-IN-2 is a potent inhibitor of acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) with an IC50 of 3.4 nM.

MGAT2-IN-4 (compound 33) is a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with liver metabolic stability, applicable in obesity, diabetes, and non-alcoholic steatohepatitis (NASH) research [1].

BMS-963272 is a selective and potent MGAT2 inhibitor with an IC50 value of 7.1 nM used in the study of metabolic disorders and obesity.

BMS-986172 is an orally active, highly selective inhibitor of MGAT2, with inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2). It exhibits an in vitro half-life (T1 2) greater than 120 minutes and is known to decrease food intake and body weight. This compound is promising for research in metabolic disorders, including obesity and non-alcoholic steatohepatitis (NASH) [1].

S-309309 is an orally active, selective MGAT2 inhibitor that can be utilized in metabolic-related research.