macrophylla

Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway.

Secaubryenol is a 3,4-secocycloartane triterpenes isolated from Coussarea macrophylla.

Corynoxine hydrochloride, a tetracyclic oxindole alkaloid extracted from the hooks of Uncaria macrophylla, functions as a natural autophagy enhancer, facilitating the removal of alpha-synuclein by activating the Akt/mTOR pathway [1].

(+)-Licarin A (Compound 7), an octanoid neolignan, is derived from the leaves of Ocotea macrophylla Kunth [1].

Apocynol A is a natural product from Hydrangea macrophylla.

Hydrangeic acid is an orally effective stilbene-type glycolipid metabolism regulator that lowers blood glucose and lipids. This compound can be isolated from processed leaves of Hydrangea macrophylla var. thunbergii. It is linked to glucose-lipid metabolism and insulin sensitivity regulation. Hydrangeic acid does not directly activate PPARγ or PPARα; instead, it enhances the mRNA expression of adiponectin, PPARγ2, GLUT4, and fatty acid-binding protein aP2 while reducing TNF-α mRNA levels, thereby promoting adipogenesis, glucose uptake, and GLUT4 translocation in 3T3-L1 cells. Additionally, it suppresses the production of NO induced by inflammatory factors, improving insulin resistance. Hydrangeic acid is useful for research related to type 2 diabetes and does not cause liver weight gain.

Erythrocentauric acid is a natural product from Gentiana macrophylla.

Hemiphroside A is a natural product from Hydrangea macrophylla.

(-)-Phyllocladene is a natural product from Callicarpa macrophylla.

6alpha-Hydroxynidorellol is a natural product from Callicarpa macrophylla.

Phyllodulcin, an orally active sweetener discovered in Hydrangea macrophylla var. thunbergii, functions as a non-selective phosphodiesterase inhibitor that mitigates allergic reactions by suppressing the activation of lymphocytes. Additionally, it combats obesity through the regulation of leptin levels, genes associated with fat browning, and the hypothalamic BDNF-TrkB signaling pathway.