macitentan

Macitentan (ACT-064992) is an endothelin receptor antagonist utilized in the treatment of pulmonary arterial hypertension (PAH).

Macitentan n-butyl analogue, a derivative of Macitentan, functions as an orally active dual antagonist targeting both endothelin ETA and ETB receptors. This compound shows promise for treating idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH), leveraging its non-peptide structure for potential therapeutic applications.

Macitentan-D4 is a deuterated substitute for Macitentan (T2561) and can be used as a dual antagonist of the non-peptides ETA and ETB (endothelin receptor).Macitentan-D4 is less toxic than Macitentan, has a longer half-life, and can be used to study endothelin receptor-mediated diseases.

N-Despropyl Macitentan-D4 is a deuterated compound of N-Despropyl Macitentan. N-Despropyl Macitentan (T7817) has a CAS number of 1103522-45-7. Aprocitentan is ETA and ETB antagonist .

Macitentan-[13C2, D4] (Standard) is a reference standard of Macitentan-[13C2, D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Despropyl Macitentan-[13C2, D4] (Standard) is a reference standard of Despropyl Macitentan-[13C2, D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Aprocitentan-D4 is a deuterium-labeled Aprocitentan. Aprocitentan (T7817) is a major and pharmacologically active metabolite of Macitentan. Aprocitentan (T7817) is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5).

ACT-373898 is a metabolite of the endothelin (ET) receptor type A (ETA) and ETBdual antagonist macitentan .1 1.Dingemanse, J., Sidharta, P.N., Maddrey, W.C., et al.Efficacy, safety and clinical pharmacology of macitentan in comparison to other endothelin receptor antagonists in the treatment of pulmonary arterial hypertensionExpert Opin. Drug Saf.13(3)391-405(2013)

Aprocitentan (ACT-132577) is ETA and ETB antagonist .