levofloxacin

Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that inhibits the superhelical activity of bacterial DNA rotamase and prevents DNA replication. Levofloxacin is a broad-spectrum antibiotic used for the treatment of a wide range of bacterial infections.

Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.

Levofloxacin N-oxide is an inactive metabolite of the antibiotic levofloxacin . Levofloxacin N-oxide is also a degradation product of levofloxacin that is formed through exposure to daylight or hydrogen peroxide.

Desmethyl Levofloxacin, a metabolite of levofloxacin, is associated with a synthetic fluoroquinolone antibacterial drug that inhibits the super-coiling activity of bacterial DNA gyrase, thereby preventing DNA replication.

Levofloxacin sodium is a synthetic fluoroquinolones antibacterial. It inhibits the supercoiling activity of bacterial DNA gyrase, so that halting DNA replication.

Levofloxacin-D3 is a deuterated compound of Levofloxacin. Levofloxacin (T6567) has a CAS number of 100986-85-4. Levofloxacin (T6567) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

Levofloxacin-D3 (Standard) is a reference standard of Levofloxacin-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Levofloxacin-d3 is a deuterated compound of Levofloxacin. Levofloxacin has a CAS number of 100986-85-4. Levofloxacin is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

Levofloxacin carboxylic acid is a fluoroquinolone compound used in biochemical experiments and drug synthesis research.

Levofloxacin Hydrochloride Impurity A I, one of the quinolones, has a broad spectrum of antibacterial action.

Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.

Levofloxacin-D8 is a deuterated compound of Levofloxacin. Levofloxacin (T6567) has a CAS number of 100986-85-4. Levofloxacin (T6567) is a broad-spectrum antibiotic topoisomerase II and topoisomerase IV inhibitor, used to treat respiratory, urinary tract, gastrointestinal, and abdominal infections.

Levofloxacin-13C,D3 is a carbon-13 and deuterium-labeled version of Levofloxacin (TMSM-3455). It is a synthetic fluoroquinolone antibiotic that inhibits the DNA gyrase enzyme's supercoiling activity in bacteria, thereby preventing DNA replication.

Levofloxacin-D8 hydrochloride is the deuterated form of Levofloxacin hydrochloride (T8747).

Levofloxacin (Standard) is a reference standard for research and analysis in studies involving Levofloxacin. Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that inhibits the superhelical activity of bacterial DNA rotamase and prevents DNA replication. Levofloxacin is a broad-spectrum antibiotic used for the treatment of a wide range of bacterial infections.

Levofloxacin-13C,D3 (Standard) is a reference standard of Levofloxacin-13C,D3 intended for quantitative analysis, quality control, and related biochemical research applications. Levofloxacin-13C,d3 is a carbon-13 and deuterium-labeled version of Levofloxacin. It is a synthetic fluoroquinolone antibiotic that inhibits the DNA gyrase enzyme's supercoiling activity in bacteria, thereby preventing DNA replication.

Defluoro Levofloxacin is a reagent used in biochemical reactions.

Delafloxacin (WQ-3034) (RX-3341, ABT-492) is a fluoroquinolone antibiotic agent. It has potent inhibitory against levofloxacin-resistant Streptococcus pneumoniae strains (MIC: 0.0078-0.125 μg/ml).

Antofloxacin is a well-tolerated, orally active, and broad-spectrum 8-amino-fluoroquinolone compound that exhibits potent antibacterial properties. It demonstrates superior activity against gyrA mutation-positive Helicobacter pylori strains, particularly in strains with mutations in the Asn87 position, when compared to levofloxacin. Additionally, Antofloxacin acts as a weak but reversible inhibitor of CYP1A2 and is clinically used to treat infections caused by various bacterial species.

DHFR-IN-1 is a selective and potent inhibitor of DHFR (dihydrofolate reductase) (IC50: 40.71 nM). DHFR-IN-1 exhibited some antifungal activity and good antibacterial activity against Gram-positive and Gram-negative bacteria.DHFR-IN-1 showed good synergy with Levofloxacin with FIC (partial inhibitory concentration index) = 0.249.

BDM91288, an orally active AcrB efflux pump inhibitor of pyridinium piperazine, enhances the in vivo efficacy of levofloxacin in treating Klebsiella pneumoniae pulmonary infection in mouse models [1].