leflornithine

L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine is an enantiomer of Eflornithine.

L-Eflornithine monohydrochloride is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine. L-Eflornithine is utilized in enzymology and polyamine biosynthesis research systems to investigate irreversible inhibition kinetics of ornithine decarboxylase, including enzyme inactivation parameters (KD and Kinact) and their relationship to catalytic turnover regulation in cellular metabolic models. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is further applied in stereochemical and structure–activity relationship studies evaluating enantiomer-dependent enzyme binding and inhibition efficiency in biochemical assay systems.