kras g12d inhibitor 7

KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D.

pan-KRAS-IN-7 (Compound 25) is an inhibitor of the human tumorigenic mutant gene KRAS. It effectively suppresses the proliferation of KRAS mutant cells AsPC-1 (G12D mutant) and SW480 (G12V mutant) with an IC50 of 0.35 nM and 0.51 nM, respectively.

KRAS G12D inhibitor 19 (Compound 7) is used in cancer research [1]. As a specific inhibitor of KRAS G12D, it targets and potentially suppresses this mutation, which is frequently associated with various cancers.

KRAS G12D-IN-35 (example 7) is a potent, orally active inhibitor of KRAS G12D. It effectively suppresses p-ERK in AGS cells and significantly inhibits the proliferation of various KRAS G12D mutant cancer cell lines. Additionally, KRAS G12D-IN-35 reduces tumor growth in HPAC and GP2D mouse models. This compound is applicable for cancer research, including studies on pancreatic and colorectal cancer.