kidney development

Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2), in development for treating type 2 diabetes mellitus (T2DM). It inhibits SGLT2, responsible for at least 90% of glucose reabsorption in the kidney.

EG1, a novel specific inhibitor of Pax2 transcription activation, targets the DNA binding domain and inhibits embryonic kidney development.

Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg L against Staphylococcus aureus strains[1][2].

Glycerol or glycerin is a colourless, odourless, viscous liquid that is sweet-tasting and mostly non-toxic. It is widely used in the food industry as a sweetener and humectant and in pharmaceutical formulations. Glycerol is an important component of trigl

RET-IN-9 is a potent inhibitor of RET, a single-channel transmembrane receptor tyrosine kinase involved in kidney and enteric nervous system development, as well as in maintaining homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 is potentially useful in studying RET-related diseases, including non-small cell lung cancer and medullary thyroid cancer.

Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin receptor agonist.

Kisspeptin-10, human TFA, is a potent vasoconstrictor and angiogenesis inhibitor that also suppresses tumor metastasis through its interaction with the receptor GPR54. It is crucial for embryonic kidney development and promotes osteoblast differentiation through NFATc4-mediated BMP2 expression via the Kisspeptin-10 GPR54 signaling pathway [1].

CK7 (a Cdk2 9 inhibitor) is crucial in synthesizing Nek1 inhibitors [BSc5231] and [BSc5367].

Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10 GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression