jervine

The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

Jervine is a naturally occurring steroidal alkaloid derived from the Veratrum plant species. Over the Hedgehog signaling pathway, Jervine effectively inhibits tumor growth using three human tumor xenograft models. Jervine has the potential to advance to t

Jervine (Standard) is a reference standard for research and analysis in studies involving Jervine. The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.

Diacetyljervine is a bioactive chemical.

O-Acetyljervine is a bioactive chemical.

Tetrahydrojervine is a bioactive chemical.

Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation.

Cyclopamine (11-Deoxojervine) is a natural small molecule steroidal alkaloid extracted from plants of the genus Aconitum. Cyclopamine acts as an antagonist of the Hedgehog pathway with an IC50 of 46 nM in cellular assays. Additionally, Cyclopamine functions as a selective Smo inhibitor. Cyclopamine is applicable for research in embryonic development, tumorigenesis, and targeted therapies.