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(1)
By Target- Hedgehog/Smoothened
- Platelet aggregation(1)
- Smo(1)
- Others(4)
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Results for "
jervine
" in TargetMol Product Catalog- Inhibitors & Agonists6
- Natural Products2
Jervine
Iervin, 11-Ketocyclopamine, Jerwiny
T3363469-59-0
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
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Pseudojervine
Jervin-3-glucoside, O-beta-D-Glucopyranosyljervine
TN234336069-05-3
Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation.
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