itaconate

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

Monomethyl itaconate serves as a copolymerization agent and is an active metabolite of the prodrug SCD-153. Additionally, it has been detected in U. maydis. This compound has applications in the creation of copolymeric hydrogels for producing methotrexate-containing polymer disks and is also utilized in synthesizing thrombin inhibitors.

4-Octyl itaconate-Bn-S-NH2 (Compound 8b) functions as a vasorelaxant. It releases H₂S slowly and steadily, helping to reduce oxidative stress through antioxidant reactions that depend on Nrf2 activation. It also inhibits the generation of intracellular ROS and cytotoxicity caused by H₂O₂ damage and activates the potassium channel. This compound is applicable in hypertension research.

4-Octyl itaconate-13C5-1 is the 13C-labeled version of 4-Octyl itaconate (T4580). Itaconate serves as an anti-inflammatory metabolite that activates Nrf2 through the alkylation of KEAP1.

4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING.

Dimethyl Itaconate is a chemical reagent used in the synthesis of functionalized 2-isoxazolines used in fragment-based drug discovery.

Monoethyl itaconate, a free radical, can be utilized for polymerization.