itaconate

4-Octyl Itaconate, a cell-permeable derivative of Itaconate, is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 and inhibits phosphorylation of STING.

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

Dimethyl Itaconate is a chemical reagent used in the synthesis of functionalized 2-isoxazolines used in fragment-based drug discovery.

Monoethyl itaconate, a free radical, can be utilized for polymerization.

Monomethyl itaconate serves as a copolymerization agent and is an active metabolite of the prodrug SCD-153. Additionally, it has been detected in U. maydis. This compound has applications in the creation of copolymeric hydrogels for producing methotrexate-containing polymer disks and is also utilized in synthesizing thrombin inhibitors.