hsc-4 cells

Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

(6-O-p-Coumaroyl)-β-D-glucopyranosyl-2-O-(4-hydroxybenzoyl)-4-O-β-D-glucopyranosyl-6-hydroxyphenylacetate is a selective inhibitor of α-glucosidase (IC50 = 10.53 μg/mL), exhibiting both anti-fibrotic and anti-diabetic properties. It inhibits the growth of mouse hepatic stellate cells (t-HSC/Cl-6) with an IC50 of 109.2 μg/mL. This compound can be isolated from ester derivatives of Impatiens balsamina L. flowers and is applicable in research focused on liver fibrosis and type 2 diabetes.

Pinocembrin 7-O-[4",6"-(S)-HHDP]-β-D-glucoside, is a complex polyphenol compound that has been shown to exhibit modest antiproliferative effects in platelet-derived growth factor (PDGF)-induced HSC-T6 hepatic stellate cells with an IC50 of 200 μM. further experiments confirm that Pinocembrin 7-O-[4",6"-(S)-HHDP]-β-D-glucoside possesses a more remarkable anti-proliferative effect specifically against activated hepatic stellate cells (HSCs), which are key drivers of liver fibrosis.