hpk1 in 7

HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

PROTACHPK1 Degrader-7 (compound D02) is a potent and selective PROTACHPK1 degrader with a DC50 of 3.07 nM, showing selectivity for GLK. It induces HPK1 degradation in a CRBN and proteasome-dependent manner. Additionally, PROTACHPK1 Degrader-7 inhibits the phosphorylation of SLP-76 and stimulates the secretion of IL-2 and IFN-γ by human primary T cells, making it useful for immunological research.

HPK1-IN-67, an HPK1 inhibitor, acts as a ligand for target proteins in PROTAC. It is utilized in the synthesis of PROTACs, such as PROTACHPK1 Dagrader-7.