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(1)
By Target- Acyltransferase
- Hedgehog/Smoothened(1)
- Others(3)
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Results for "
hhat
" in TargetMol Product Catalog- Inhibitors & Agonists4
RU-SKI 43
RUSKI 43
T127971043797-53-0In house
RU-SKI 43 is a potent and selective hedgehog acyltransferase (Hhat) inhibitor with an IC50 of 850 nM. It exhibits anticancer activity and is a potential treatment for lung adenocarcinomas. RU-SKI 43 reduces Gli-1 activation through smoothening-independent non-canonical signaling and inhibits Akt and mTOR pathway activity.
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RU-SKI 43 hydrochloride
T12797L1782573-67-4
RU-SKI 43 hydrochloride is a potent and selective inhibitor of Hedgehog acyltransferase (Hhat) with an IC50 of 850 nM and exhibits anti-cancer activity.
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RUSKI-201
RU-SKI-201
T344511458031-48-5
RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.
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RUSKI-201 dihydrochloride
T623882320262-09-5
RUSKI-201 dihydrochloride is a potent and specific inhibitor of Hedgehog acyltransferase (Hhat) (IC50: 0.20 μM). It blocks Hh signaling in Shh-overexpressing cells and inhibits Hh palmitoylation. RUSKI-201 dihydrochloride is a promising Hhat chemical probe for studying Hhat catalytic function.
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