hdat

Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Maleate is the maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property.

SRI-32743 serves as an allosteric modulator of the human dopamine transporter (hDAT) with an IC50 of 9.86 μM. It is potentially valuable for research focused on neurotoxicity induced by HIV-Tat.

DAM-001 (Z236004662) is a potent non-competitive allosteric inhibitor of the human dopamine transporter (hDAT). It exhibits an IC50 of 24.70 μM in the absence of the orthosteric inhibitor Nomifensine and 1.026 μM when Nomifensine is present.

Trimipramine N-oxide, an active metabolite of the tricyclic antidepressant trimipramine, effectively inhibits human monoamine transporters for noradrenaline (hNAT), serotonin (hSERT), dopamine (hDAT), and the human organic cation transporters (hOCT1 and hOCT2), with IC50 values of 11.7, 3.59, 9.4, 9.35, and 27.4 nM, respectively. It is utilized in the research of depression and anxiety [1].

Z1078601926 is an allosteric inhibitor of the human dopamine transporter (hDAT) and exhibits a synergistic effect when combined with Nomifensine [1].

MRS7292 is a non-competitive inhibitor of the human dopamine transporter (hDAT). It functions by inhibiting dopamine transport.

AC-4-248 is an atypical, noncompetitive inhibitor of the dopamine transporter (DAT) that can reduce the inhibitory potency of cocaine on DAT. Additionally, it is a non-selective inhibitor of SLC6 transporters, with IC50 values of 45.5 μM for hDAT, 96.2 μM for hSERT, and 250 μM for hNET.