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(2)
By Target- Epigenetic Reader Domain
- Histone Methyltransferase(1)
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By Target By ResearchField- Cancer(2)
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Results for "
h4k20me1
" in TargetMol Product Catalog.- Inhibitors & Agonists3
- UNC926UNC-926, UNC 926T40121184136-10-4UNC926 (UNC-926) inhibits L3MBTL1 (IC50: 3.9 μM). UNC926 also exhibits a low micromolar affinity for L3MBTL3. UNC926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MBTL13xMBT-H4K20me1 interaction. UNC926 has not an effect on the binding of 53BP1 to H4K20me1.
- $30
SizeQTY - UNC926 hydrochlorideT92211782573-49-2UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
- $80
SizeQTY - MS2928T218845MS2928 is a selective inhibitor of SETD8 with an IC50 of 0.14 μM for inhibiting the methyltransferase activity of SETD8. It reduces intracellular H4K20me1 levels and inhibits the proliferation of multiple myeloma cells that overexpress SETD8. Additionally, MS2928 suppresses tumor growth in xenograft mouse models of multiple myeloma with SETD8 overexpression. This compound can be utilized in research on SETD8's biological functions and multiple myeloma.
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