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Results for "
gsk1059865
" in TargetMol Product Catalog- Inhibitors & Agonists1
GSK1059865
GSK-1059865, GSK 1059865
T114771191044-58-2
GSK1059865 is a highly selective orexin-1 receptor antagonist that significantly reduces voluntary ethanol intake in ethanol-dependent mice following chronic intermittent ethanol exposure, producing dose-dependent suppression of alcohol consumption without affecting sucrose intake, while exhibiting minimal effects in non-dependent controls except at high doses, thereby highlighting its utility for investigating orexin signaling in alcohol dependence and addictive behaviors.
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