gpr65

BTB09089 (GPR65 agonist ) is a T cell death-associated gene 8 (TDAG8 GPR65)-specific agonist.BTB09089 induces TDAG8 expression and regulates cytokine production in T cells and macrophages.

BRD5080 is an effective positive allosteric modulator of GPR65, capable of inducing GPR65-dependent cAMP production. It demonstrates potent cAMP activity induction and G protein recruitment in both WT and mutant hGPR65, as well as its murine orthologs. With these capabilities, BRD5080 holds potential for use in research focused on autoimmune and inflammatory diseases.

BRD5075 is an effective activator of GPR65, stimulating the production of cAMP in a GPR65-dependent manner. Additionally, it reduces the gene expression of IL-1, IL-2, TNF, and chemokines. BRD5075 holds potential for researching multiple sclerosis and inflammatory bowel disease (IBD).