gpr171

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

MS21570 as a GPR171 antagonist based on its ability to block,with an IC50 of 220 Nm,that reduces anxiety-like behavior and fear conditioning in mice.

BigLEN (mouse) acetate is a potent and selective agonist of orphan G protein-coupled receptor 171 (GPR171), with a Kd of ∼0.5 nM.

BigLEN(rat) is a potent GPR171 agonist with an EC50 of 1.6 nM [1].

BigLEN(mouse) TFA is a proSAAS-derived neuropeptide and GPR171 agonist that both regulates food intake in mice and inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus, a mechanism contingent on postsynaptic G protein activation.

GPR171 agonist. ProSAAS-derived neuropeptide. Regulates food intake in mice. Inhibits the release of glutamate onto parvocellular neurons of the paraventricular nucleus in a process dependent upon activation of postsynaptic G proteins.

Potent GPR171 agonist (EC50 = 1.6 nM). ProSAAS-derived peptide. Regulates body weight in mice and promotes the outgrowth of neurites in Neuro2A cells.