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By Target- Hedgehog/Smoothened
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Results for "
gli1 mrna
" in TargetMol Product Catalog- Inhibitors & Agonists3
TAK-441
TAK441
T213251186231-83-3
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expression and tumor growth.
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TPB15
T627722170347-69-8
TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. TPB15 has good anti-tumour effects and low toxicity.
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