gambogic acid

Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.

Gambogic acid A is a useful organic compound for research related to life sciences and the catalog number is T125707.

Gambogic acid B, isolated from Garcinia hanburyi resin, exhibits cytotoxic effects on A549, HCT116, and MDA-MB-231 cell lines with respective IC50 values of 1.60 µM, 6.88 µM, and 0.87 µM [1].

Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors [resulting in an anticancer effect], and may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.

Gambogic Acid (Standard) is a reference standard for research and analysis in studies involving Gambogic Acid. Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.

Isogambogic acid (C2-S) is a natural xanthonoid compound and a structural isomer related to Gambogic acid. Isogambogic acid (C2-S) can be used as a reference compound in natural product studies, particularly in pharmacological and biochemical research.

30-Hydroxygambogic acid is a useful organic compound for research related to life sciences and the catalog number is T124009.

9R-10alpha-Hydroxyepigambogic acid is a useful organic compound for research related to life sciences and the catalog number is T126415.

Epigambogic acid is a small molecule compound from Garcinia Cambogia with anti-tumor, antitussive, expectorant and anti-inflammatory activities.

"S-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboges of Garcinia hanburyi, exhibits cytotoxicity against Human Leukemia K562 cell lines with IC50 values of 4.49 μM for K562/R and 3.61 μM for K562/S. This compound is utilized in cancer research [1]."

R-30-Hydroxygambogic acid, a polyprenylated xanthone epimer isolated from the gamboge of Garcinia hanburyi, exhibits cytotoxicity against human leukemia K562 cell lines, with IC50 values of 2.89 μM for the resistant strain (K562/R) and 1.27 μM for the sensitive strain (K562/S). This compound is utilized in cancer research [1].

8,8a-Dihydro-8-hydroxygambogic acid, a natural compound extracted from the resin of Garcinia hanburyi, exhibits anticancer activity [1].

10α-Hydroxyepigambogic acid, extracted from Garcinia hanburyi, is utilized in tumor research [1].

Neogambogic acid (Standard) is a reference standard for research and analysis in studies involving Neogambogic acid. Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors and result in an anticancer effect, it may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.

Isogambogic acid is a xanthone-type natural product isolated from plants of the Garcinia genus (Garcinia hanburyi). Isogambogic acid exhibits significant cytotoxic activity and has been shown in vitro to inhibit human epidermoid carcinoma KB cells as well as the drug-resistant KB-V1 cell line.

HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT). Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.