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- Dye Reagents1
Gallocyanine
T355511562-85-2
Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5 6 (IC50 = 3 μM), thereby activating Wnt β-catenin signaling. Modulation of the Dkk1-LRP5 6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.
- $30
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