gallocyanine

Gallocyanine is a synthetic azine-based blue dye and a potent inhibitor of DKK1/LRP6 interaction (IC₅₀ = 6.38 μM). It selectively activates the Wnt signaling pathway by blocking the binding of DKK1 to its receptor LRP6, thereby inhibiting the antagonistic effects of this pathway and inducing intracellular β-catenin accumulation. Gallocyanine exhibits antitumor metastasis, anti-inflammatory, and antifibrotic activities and can be used in research related to tumors, inflammatory injuries, and neurodegenerative diseases. Gallocyanine is a histological stain that specifically labels nucleic acids and cell nuclei; it can also serve as a biochemical fluorescent probe for the detection of superoxide anion radicals.