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fr-900506

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Tacrolimus
Fujimycin, FR900506, FK506
T2144104987-11-3
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium calmodulin-dependent protein phosphatase.
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Tacrolimus-13C-d2
TMIH-05481356841-89-8
Tacrolimus-13C-d2 is the 13C and deuterated compound of Tacrolimus.
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7-10 days
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Tacrolimus monohydrate
Tacrolimus hydrate, Prograf, LCP-Tacro, FR900506, FR 900506, FK-506, FK 506
T20879109581-93-3
Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo.
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