fluorodeoxyuridine

2′,2′-Difluorodeoxyuridine (dFdU), the major metabolite of Gemcitabine, exhibits anticancer and antitumor activities, shows radiosensitization under hypoxic conditions, and can be used to study pancreatic cancer.

5-Fluoroorotic acid (monohydrate) (5-Fluorouracil-6-carboxylic acid Mono(hydrate); 5-FOA) is employed to detect the expression of the URA3 gene in yeast molecular genetic constructs. Yeast possessing an active URA3 gene (which encodes orotidine-5'-monophosphate decarboxylase) convert 5-FOA into 5-fluorodeoxyuridine, a substance toxic to cells. Yeast strains with mutations in the URA3 gene that confer resistance can grow in the presence of 5-FOA if uracil is added to the medium.

Fosifloxuridine nafalbenamide (NUC 3373), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor. NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.