fl118

FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway, thereby inhibiting migration and invasion of human breast cancer cells.

FL118 inhibits human survivinion expression and activates tumor suppressor p53 as a MOA in p53 wild-type cancer cells.

CL2A-FL118 is a drug-linker that serves as a component for synthesizing the ADC molecule Sac-CL2A-FL118.

FL118-14-Propanol is a cytotoxic camptothecin derivative, a potential topoisomerase I inhibitor with potential antitumor activity, which can be used in the synthesis of ADC compounds.

FL118-C3-O-C-amide-C-NH2 format serves as an ADC linker in the creation of active synthetic antibody conjugate molecules (ADCs).

FL118-C3-O-C-amide-C-NH2 (compound 6a) serves as an ADC linker in the production of antibody-drug conjugates (ADCs) [1].

FL118-C3-O-C-amide-C-NH2-D5 formate is a deuterium-labeled derivative of FL118-C3-O-C-amide-C-NH2 formate, which functions as an ADC (Antibody Drug Conjugate) linker used in the synthesis of active conjugated antibodies.

FL77-24, an analog of FL118 and an apoptosis inducer, exhibits antitumor activity with IC50 values of 99.4 nM in HCT116 cells, 118 nM in HepG2 cells, less than 6.4 nM in both MCF-7 and HeLa cells, and 28.5 nM in A549 cells. It primarily induces cell cycle arrest in the S and G2/M phases [1].