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By Target- Nucleoside Antimetabolite/Analog
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Results for "
ethynylcytidine
" in TargetMol Product Catalog- Inhibitors & Agonists3
Ethynylcytidine
ECyD, 3'-C-Ethynylcytidine, TAS-106
TQ0006180300-43-0
Ethynylcytidine is a nucleoside antimetabolite.
Inquiry
2'-beta-C-Ethynylcytidine
TNU0473188413-99-2
2'-beta-C-Ethynylcytidine is a Nucleoside Derivative - 2'-Modified nucleoside.
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5'-Ethynyl-2'-deoxycytidine
EdC,2'-deoxy-5-Ethynylcytidine,Click Tag™ 5'-Ethynyl-2'-deoxycytidine
T8438069075-47-4
5'-Ethynyl-2'-deoxycytidine (EdC) functions as a nucleoside analog effectively inhibiting the replication of herpes simplex virus-1 (HSV-1) KOS strain with an ID50 of 0.2 μg/mL. Additionally, it decreases virus-induced cytopathogenic effects in PRK cells for HSV-1, HSV-2, and vaccinia virus strains, demonstrating MIC values between 0.2 to 5 μg/mL. EdC acts as a thymidylate synthetase inhibitor, selectively impacting the DNA incorporation rates of [1',2'-3H]deoxyuridine compared to [CH3-3H]deoxythymidine in PRK cells with ID50s of 3 and 120 μg/mL, respectively. It further inhibits thymidine synthetase and curtails L1210 cell proliferation, a process reversible by deoxythymidine (ID50s are 4.4 and 1,000 μg/mL, respectively). Also, EdC is utilized in monitoring DNA synthesis and cellular replication through click chemistry conjugation, linking its ethynyl group with the azido group of various fluorochromes.
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