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(2)
By Target- Estrogen Receptor/ERR
- PROTACs(1)
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Results for "
esr1 y537s
" in TargetMol Product Catalog- Inhibitors & Agonists2
- PROTAC Products1
Vepdegestrant
Cited
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
- $186
Size
QTY
CitedGLL 398
T99972077980-80-2
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
- $195
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QTY
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