eif4a3-in-2

eIF4A3-IN-2 is a highly selective and noncompetitive inhibitor of eukaryotic initiation factor 4A-3, exhibiting an IC50 of 110 nM.

(R)-eIF4A3-IN-2, a less active enantiomer of eIF4A3-IN-2, is a highly selective and noncompetitive inhibitor of the eukaryotic initiation factor 4A-3 (eIF4A3) with an IC50 of 110 nM.

eIF4A3-IN-18, a silvestrol analogue, disrupts the formation of the eIF4F translation complex, exhibiting EC 50 values of 0.8, 35, and 2 nM for myc-LUC, tub-LUC, and the growth inhibition of MBA-MB-231 cells, respectively. Additionally, it demonstrates cytotoxicity towards RMPI-8226 cells with an LC 50 of 0.06 nM. This compound is utilized in researching human cancer pathogenesis [1].