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Mepolizumab (SB 240563) is a humanized monoclonal antibody that neutralizes IL-5, and can be utilized in research on severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis.

DSPE-PEG-PA (MW 2000) is a PEG lipid designed to enhance the delivery efficiency and tissue specificity of poorly soluble drugs. It is applicable in research focused on drug delivery.

mPEG-pALD (MW 5000) is a significant monofunctional PEG derivative with reactive groups that can interact with the N-terminus of amines, peptides, and proteins to form imines containing a C=N double bond, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives are capable of forming hydrolytically stable acyl hydrazone bonds through reaction with hydrazine or hydrazide for reversible PEGylation.

mPEG-pALD (MW 1000) is a crucial mono-functional PEG derivative. It contains reactive groups capable of reacting with the N-terminus of amines, peptides, and proteins to form imines with C=N double bonds, which can be further reduced. Polyethylene glycol aldehydes or ketone derivatives can form hydrolysable acylhydrazone bonds through reactions with hydrazine or hydrazides, enabling reversible PEGylation.

mPEG-pALD (MW 40000) is a significant mono-reactive PEG derivative with reactive groups that can interact with the N-terminus of amines, peptides, and proteins, forming an imine with a C=N double bond that can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can create hydrolyzable acylhydrazone bonds for reversible PEGylation through reactions with hydrazine or hydrazides.

mPEG-pALD (MW 20000) is a significant mono-reactive PEG derivative, equipped with reactive groups that can react with the N-terminus of amines, peptides, and proteins to form an imine containing a C=N double bond, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can form hydrolysable acylhydrazone bonds through reactions with hydrazine or hydrazide, making them suitable for reversible PEGylation.

mPEG-pALD (MW 10000) is a significant mono-functional PEG derivative, featuring reactive groups that can engage with the N-terminus of amines, peptides, and proteins to form an imine containing a C=N double bond, with the potential for further reduction. Polyethylene glycol aldehyde or ketone derivatives can produce hydrolytically cleavable acylhydrazone bonds through reaction with hydrazine or hydrazides for reversible PEGylation.

mPEG-pALD (MW 2000) is a significant unidirectional reactive PEG derivative, featuring a reactive group that can interact with the N-terminus of amines, peptides, and proteins, forming an imine with a C=N double bond, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can form hydrolytically cleavable acylhydrazone linkages through a reaction with hydrazine or hydrazides, suitable for reversible PEGylation.

mPEG-pALD (MW 3400) is a significant mono-reactive PEG derivative featuring reactive groups that can bond with the N-terminus of amines, peptides, and proteins to create imines with C=N double bonds, which can be further reduced. Polyethylene glycol aldehyde or ketone derivatives can form hydrolytically cleavable acylhydrazone bonds through reaction with hydrazine, enabling reversible pegylation.