dub-in-1

DUB-IN-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).

DUB-IN-8 (Compound 8q) serves as an inhibitor of Chlamydia deubiquitinase 1 (DUB1) with an IC50 of 7.7 μM. It exhibits antibacterial properties by inhibiting Chlamydia inclusions, with an IIC50 [the concentration to induce 50% inclusion inhibition] of 8.5 μg/mL.

BAY-805 is a selective, high-affinity inhibitor of the ubiquitin-specific protease USP21 and an in vitro chemical probe. It possesses low nanomolar affinity and enhances NF-κB levels.

DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].

(R)-CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.