dota derivative

DOTA derivatives are phenoxy derivatives of cyclic Tosamide;Direct nitrification;It is more convenient to add nitro group after removing the protection of lithium aluminium hydride.

2-Aminoethyl-mono-amide-DOTA-tris(tBu ester) is a macrocyclic DOTA derivative developed for tumor pretargeting.

DOTA tert-butyl ester is a phenyl derivative of cycloteramide; it can be directly nitrated; it is more convenient to add nitro after deprotection of lithium aluminum hydride.

PSMA617-TCMC is a derivative of PSMA-617 with structure modification, in which the caroboxy groups in DOTA ring is replaced by TCMC macrocycle. PSMA-617 is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.

DOTA-tris(tBu)ester NHS ester, a derivative of DOTA, serves for the labeling of peptides and antibodies.

DOTA-LM3 is a somatostatin receptor (SSTR) antagonist, with LM3 denoting the peptide sequence p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2. It is utilized in the isotopic labeling of tumors for in vivo tracing, notably with 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. The derivative 68Ga-DOTA-LM3 exhibits promising biodistribution, high tumor uptake, efficient tumor retention, and minimal safety concerns, while 177Lu-DOTA-LM3 is applied in research on DOTATOC-negative liver metastases including pancreatic NET and extensive tumor thrombosis [1] [2].

Fmoc-D-Dap(Boc)-OH, an amino acid derivative featuring an Fmoc protecting group, is utilized in the synthesis of bioactive peptide mimetics, including DOTA-modified peptides and their metal chelates, which are noted for their cancer diagnostic capabilities.

DOTA-EB-TATE is formed by combining the SST peptide derivative DOTA-octreotate with an Evans blue analog (EB). This peptide drug conjugate (PDC) enhances the pharmacokinetics of SSTR2 analogs and reduces PRRT toxicity. Additionally, DOTA-EB-TATE serves in the synthesis research of radiopharmaceutical conjugates (RDC).

(S)-p-SCN-Bn-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC), serving as a macrocyclic DOTA derivative for tumor pre-targeting. It is utilized for the conjugation of peptides and radionuclides.

Butyne-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC), serving as a macrocyclic DOTA derivative designed for tumor pre-targeting applications. It is utilized for the conjugation of peptides and radionuclides.

DOTA-amide is a bifunctional chelator (Bifunctional Chelator; BFC) that serves as a macrocyclic DOTA derivative for tumor pretargeting. It's suitable for conjugation with peptides and radionuclides.

Azido-mono-amide-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative designed for tumor pretargeting. It facilitates the conjugation of peptides and radionuclides.

DOTAM-mono-acid is a bifunctional chelator (BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. It is suitable for conjugation with peptides and radionuclides.

DOTA-Thiol is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative intended for tumor pretargeting. It is suitable for conjugation with peptides and radionuclides.

DOTAM-NHS-ester is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized in tumor pre-targeting. It is suitable for conjugation with peptides and radionuclides.

(R)-tetraMe-Tetraxetan is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. It is useful for conjugation with peptides and radionuclides.

p-NH2-Bn-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC), serving as a macrocyclic DOTA derivative for tumor pretargeting applications. It enables the conjugation of peptides and radionuclides.

Maleimido-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) that serves as a macrocyclic DOTA derivative for tumor pretargeting. It is applicable for the conjugation of peptides and radionuclides.

Butyne-DOTA-tris(t-butyl ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized for tumor pre-targeting. It is suitable for conjugation with peptides and radionuclides.

4-Aminobutyl-DOTA-tris(t-butyl ester) is a bifunctional chelator (Bifunctional Chelator;BFC) and serves as a macrocyclic DOTA derivative for tumor pre-targeting. It is suitable for conjugating peptides and radionuclides.

p-NH2-Bn-DOTA-tetra(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized in tumor pre-targeting. It is applicable for the conjugation of peptides and radionuclides.

4-Aminobutyl-DOTA is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative utilized for tumor pre-targeting. It is applicable for conjugation with peptides and radionuclides.

Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative designed for tumor pre-targeting applications. It serves as a coupling agent for peptides and radionuclides.