dinucleotide

Flavin adenine dinucleotide disodium salt (FAD sodium salt) is a flavin dinucleotide that is synthesized when the AMP moiety from ATP is transferred onto riboflavin 5'-monophosphate. FAD functions as a coenzyme that facilitates the transfer of electrons by flavoenzymes in oxidation-reduction reactions in cells.

Flavin adenine dinucleotide (FAD) is a REDOX cofactor and protein cogroup involved in various metabolic reactions.

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD that serves as a fluorescent substrate for studying ADP-ribosylation reactions.

Phytic acid dipotassium salt is an endogenous metabolite that inhibits β-secretase 1 (BACE1).

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).

Deaminocozymase also known as Nicotinamide-hypoxanthine dinucleotide, is a biochemical.

NAD sodium (β-DPN sodium) is distributed across all human cells, involved in thousands of biochemical reactions, and is an essential coenzyme in the body.

Thio-NAD, a thione-modified derivative of the signaling molecule and enzyme cofactor NAD+, can substitute for NAD+ as a cofactor in alkaline phosphatase (ALP) enzyme activity assays. It is utilized as a substrate in dual-enzyme cycling ELISA for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein, or surface glycoprotein, and live M. tuberculosis in patient sputum. Thio-NAD is characterized by its absorbance at 405 nm, distinguishing it from other cofactors.

8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-α and IL-2 in mouse primary microglial cells.

6-alkyne NAD+ sodium (6-Parg NAD sodium) is a clickable signaling molecule and enzyme cofactor in NAD+ form. It is used in conjunction with fluorescence labeling for detecting poly(ADP-ribose) polymerase (PARP) protein substrates.

6-Biotin-17-NAD+ sodium (Biotin-LC-NAD+ sodium) is a biotinylated derivative of NAD+ and can be used to measure NADH dehydrogenase activity.

ε-NAADP+ is a fluorescent derivative of NAADP, known for inducing calcium mobilization. It effectively induces calcium release in sea urchin egg homogenates with an EC50 of 5 µM. The compound exhibits excitation and emission maxima at 275 nm and 410 nm, respectively. Notably, its emission intensity increases three-fold when dissolved in DMSO.

8-(2-azidobenzylthio) NAD+ is a derivatized version of NAD+, a signaling molecule and enzyme cofactor, featuring an azido group (azidobenzylthio) that enables click chemistry applications.

8-(4-Azidophenacylthio) NAD+ is a clickable variant of the essential signaling molecule and enzyme cofactor, NAD+.

2-Azido-NAD, an analog of NAD+, is utilized for visualizing the intracellular poly (ADP-ribosyl)ation (PARylation) process.

2',3'-Cyclic NADP disodium (2',3'-cNADP+; β-Nicotinamide adenine dinucleotide-2',3'-cyclic phosphate) is a substrate of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP), an enzyme abundantly found in the myelin. It is utilized in coupled enzyme assays for the quantification of CNP activity. At a concentration of 5 μM, 2',3'-cNADP disodium can enhance calcium release due to calcium overload and prevent calcium-induced swelling in rat brain mitochondria.

α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for the enzyme renin and functions similarly to β-NAD analogs. It influences the kinetics of NAD-dependent enzymes and plays a crucial role as a cofactor in mitochondrial redox reactions.

NAD+ lithium (β-DPN lithium) is the lithium salt form of nicotinamide adenine dinucleotide. This coenzyme plays a crucial role in redox reactions and can directly or indirectly influence various key cellular functions, such as metabolic pathways, DNA repair, chromatin remodeling, cell aging, and immune cell functions.

N6-Etheno-nicotinamide dinucleotide phosphate (ε-NADP+) trisodium is a structural analog of NADP(+). It acts as an inhibitor of maize malic enzyme with a Ki value of 1.01 μM.

Flavin Adenine Dinucleotide DiSodium Salt xhydrate is a useful organic compound for research related to life sciences and the catalog number is T64590.

β-Nicotinamide adenine dinucleotide reduced dipotassium is an orally active, reduced coenzyme that functions as a donor of ADP-ribose units in ADP-ribosylation reactions and as a precursor of cyclic ADP-ribose. It also serves as a regenerative electron donor in essential cellular energy metabolism processes, including glycolysis, β-oxidation, and the tricarboxylic acid (TCA) cycle [1].

β-Benzamide adenine dinucleotide is a bioactive metabolite of benzamide ribonucleoside and functions as an effective inhibitor of inosine monophosphate dehydrogenase (IMPDH). It also acts as a potent, competitive inhibitor of human NAD kinase with a Ki value of 90 µM.

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) sodium is a fluorescent analog of NAD, serving as a substrate for bacterial toxins that catalyze the G-ADP ribosylation of signal-transduction G proteins. Additionally, Nicotinamide 1,N6-ethenoadenine dinucleotide sodium can be used as a fluorescent substrate in the study of ADP ribosylation reactions.