dihydrosphingosine

Dihydrosphingosine is a Protein kinase C inhibitor.

D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) inhibits arachidonic acid release and cPLA2α activity.

Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a specific inhibitor of protein kinase C. It induces autophagy in solid tumor cells and cancer cell death by inhibiting the PKC and PI3-kinase pathways.BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor. Safingol hydrochloride inhibits PKC and PI3k.

C16 dihydro Ceramide (d18:0/16:0) (Cer(d18:0/16:0)) is a precursor for the synthesis of ceramides, induces autophagy in the perinuclear region, and can be used to study cell membrane stability and neurological diseases.

Sphinganine 1-phosphate is an intermediate in the sphingolipid metabolic pathway and is structurally similar to sphingosine. It has a protective effect on the kidney and liver through activation of the S1P1 receptor in mice. D-erythro-Dihydrosphingosine 1-phosphate acts as an agonist for S1P4 in Homo sapiens and may activate GPR63 (G protein-coupled receptor), mainly used in the study of Fabry disease, Gaucher disease, Krabbe disease and Leukodystrophy.

C2 Dihydro Ceramide (d18:0/2:0) (C2 Dihydroceramide) is a short-chain ceramide that is a precursor of ceramide synthesis and stimulates ABCA1-mediated cholesterol efflux.

C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is a lipid molecule that can be used in life science related research. The CAS number of C24 (2'(R)-hydroxy) dihydro Ceramide (d18:0/24:0) is 164989-36-0.

3-Keto Sphinganine (d12:0) is a short-chain analog of 3-keto sphinganine (d18:0), which typically possesses a C18 chain length. The latter is a lyso-sphingolipid synthesized through the condensation of L-serine and palmitoyl-CoA mediated by the enzyme serine palmitoyl transferase (SPT). A deficiency in Vitamin K deactivates SPT, leading to a reduced synthesis of 3-keto sphinganine among other sphingolipids. [Matreya, LLC. Catalog No. 1893]

C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16((±)-2'-hydroxy) dihydro Ceramide (d18:0/16:0) is 190249-36-6.

C6 dihydro Ceramide (d18:0/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 dihydro Ceramide (d18:0/6:0) is 171039-13-7.

C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) is a lipid molecule that can be used in life science related research. The CAS number of C12((±)-2'-hydroxy) dihydro Ceramide (d18:0/12:0) is 2377379-54-7.

C17 dihydro Ceramide (d18:0/17:0) is a lipid molecule that can be used in life science related research. The CAS number of C17 dihydro Ceramide (d18:0/17:0) is 1388156-40-8.

D-Erythro-dihydrosphingosine-d7 is a deuterated form of D-Erythro-dihydrosphingosine. It directly inhibits the activity of phospholipase A2α (cPLA2α) in the cytosol.

(2S)-3-Keto sphinganine (d6:0) ((2S)-3-Keto-C6-dihydrosphingosine) hydrochloride is a lipid compound utilized in the preparation of liposomes. Liposomes, characterized by concentric phospholipid bilayer vesicles, are critical in constructing drug delivery systems for anti-cancer and anti-infection applications. They effectively encapsulate hydrophilic solutes within their aqueous interiors and incorporate lipophilic cargoes into their phospholipid bilayers, making them integral to the bilayer structure. This compound is particularly valuable in delivering antisense oligonucleotides, addressing challenges such as inefficient cellular uptake and rapid loss in the body.

DL-threo dihydrosphingosine is a cell-permeable inhibitor of the extracellular signal-regulated kinase (ERK) signalling cassette in mammalian cells. DL-threo dihydrosphingosine is effective against both growth factor- and G-protein-dependent activation of

C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is a lipid molecule that can be used in life science related research. The CAS number of C24:1 1-Deoxyceramide (m18:1/24:1(15Z)) is 1246298-58-7.

C12 1-Deoxyceramide (m18:1/12:0) is a lipid molecule that can be used in life science related research. The CAS number of C12 1-Deoxyceramide (m18:1/12:0) is 1246298-54-3.

C16 1-Deoxyceramide (m18:1/16:0) is a lipid molecule that can be used in life science related research. The CAS number of C16 1-Deoxyceramide (m18:1/16:0) is 1246298-56-5.

A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50= <0.01 μM), an effect that is reduced in the presence of vitamin B6(EC50= <100 μM). 1.Ohtoyo, M., Tamura, M., Machinaga, N., et al.Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levelsLipids51(10)1207-1216(2016)

Sphingosine (d18:1), an amino alcohol, is chiefly recognized for its 18-carbon unsaturated hydrocarbon chain. Nevertheless, in mammalian tissues, both sphingosine and its variant, dihydrosphingosine, feature hydrocarbon chains ranging from 12 to 26 carbons. Sphingosine (d15:1) represents a naturally rare variant, serving as an internal standard for chromatographic or spectrometric analyses of sphingoid compounds.