diclofenac sodium

Diclofenac sodium (GP 45840) is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

Diclofenac sodium (Standard) is the reference standard of diclofenac sodium, suitable for quantitative analysis, quality control, biochemical experiments, and related research. Diclofenac sodium is a non-selective anti-inflammatory drug and a cyclooxygenase (COX) inhibitor. In CHO cells, its IC₅₀ values against human COX-1 and COX-2 are 4 nM and 1.3 nM, respectively; against ovine COX-1 and COX-2, they are 5.1 μM and 0.84 μM, respectively. In addition, diclofenac sodium induces apoptosis in neural stem cells by activating the caspase cascade.

2,6-Dichlorodiphenylamine, an analogue of Diclofenac Sodium, exhibits anti-Candida albicans activity. Diclofenac Sodium, a potent and nonselective COX inhibitor, has IC50 values of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells. [1]. Makoto Urai, et al. Potent Drugs That Attenuate anti-Candida albicans Activity of Fluconazole and Their Possible Mechanisms of Action. J Infect Chemother. 2014 Oct;20(10):612-5.

Diclofenac-D4 sodium is the deuterated form of Diclofenac sodium (T1555). Diclofenac Sodium (GP 45840) is an effective, non-selective anti-inflammatory agent that acts as a COX inhibitor, with IC50 values of 4 nM for human COX-1 and 1.3 nM for COX-2 in CHO cells. For sheep COX-1 and COX-2, the IC50 values are 5.1 μM and 0.84 μM, respectively. Diclofenac Sodium induces apoptosis in neural stem cells by activating the caspase cascade [apoptosis].