dbco-peg-5-dbco

DBCO-PEG5-DBCO is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

DOTA-PEG5-C4-DBCO is a PEG-based linker employed in PROTAC and bioconjugation applications, utilizing strain-promoted azide–alkyne cycloaddition (SPAAC) chemistry. The design of DOTA-PEG5-C4-DBCO enables ligation of functional ligands, facilitating targeted protein degradation via the ubiquitin–proteasome system and supporting modular assembly of advanced chemical probes.

PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker conjugate for PAC. PROTAC BRD4 Degrader-5-CO-PEG3-N3 comprises the BRD4 degrader GNE-987 linked through a PEG-based spacer to enable modular bioconjugation. PROTAC BRD4 Degrader-5-CO-PEG3-N3 functions as a click-chemistry reagent containing an azide group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-bearing molecules. PROTAC BRD4 Degrader-5-CO-PEG3-N3 can also react through strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO- or BCN-containing compounds, thereby supporting targeted PROTAC assembly and bioconjugation for chemical biology and drug-discovery applications.

5-(Azido-PEG4)-pent-2-yn-1-ol is a compound featuring an azido group and a terminal hydroxyl group within a PEG linker. The hydrophilic PEG spacer enhances solubility in aqueous media. The azido group can undergo Click Chemistry with alkynes, BCN, and DBCO, producing stable triazole bonds. The hydroxyl group can be further derivatized or replaced by other reactive functional groups.