dbco peg10 dbco

DBCO-PEG10-DBCO is a PEG-based linker used in PROTACs, joining two essential ligands needed to form PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG10-amine is a non-cleavable ADC linker and PEG-based PROTAC linker that can be used to synthesise antibody-drug conjugates (ADCs) and PROTACs. It can undergo click chemistry reactions with molecules containing alkyne, DBCO or BCN groups.

LG-PEG10-click-DBCO-Oleic is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Azido-PEG10-CH2CO2-NHS is a PROTAC linker of the PEG class, utilized for synthesizing PROTAC molecules. It serves as a click chemistry reagent, featuring an Azide group that participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG10-CH2COOH is a PROTAC linker belonging to the PEG category, useful for synthesizing PROTAC molecules. This compound is a click chemistry reagent containing an azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG10-propargyl is a PROTAC linker belonging to the PEG class, suitable for synthesizing PROTAC molecules. It features an azide group, enabling copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with molecules containing alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG10-azide is a PROTAC linker belonging to the PEG category, utilized in the synthesis of PROTAC molecules. As a click chemistry reagent, it features azide groups capable of participating in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it engages in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with DBCO or BCN-containing molecules.

Biotin-PEG10-azide (Biotin-PEG10-N3) is a PEG derivative that integrates biotin, 10 PEG units, and an azide group. Biotin can form a stable, non-covalent bond with streptavidin. The azide group allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups and enables strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN group-containing molecules.

N-(acid-PEG10)-N-bis(PEG10-azide) is a widely utilized PEG reagent featuring a terminal carboxylic acid and two azide groups. Its hydrophilic PEG spacer enhances solubility in aqueous media. The azide groups can react with alkynes, BCN, or DBCO via Click Chemistry to create stable triazole linkages. The terminal carboxylic acid can form robust amide bonds by reacting with primary amine groups in the presence of activating agents such as EDC or HATU.