dacomitinib

Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.

Dacomitinib impurity 8 is an impurity found in Dacomitinib.

Dacomitinib impurity 9 is a byproduct associated with Dacomitinib.

Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.

O-Desmethyl dacomitinib (PF-05199265) is the primary circulating metabolite of Dacomitinib and acts as a pan-ErbB tyrosine kinase inhibitor, targeting epidermal growth factor receptors. The exposure level of O-Desmethyl dacomitinib is significantly lower than that of Dacomitinib, and its formation is highly dependent on CYP2D6 enzyme activity.

Dacomitinib impurity 16 is a known impurity of Dacomitinib.

Dacomitinib impurity 4 is an impurity associated with Dacomitinib.

Dacomitinib impurity 3 is a contaminant found in Dacomitinib.

Dacomitinib impurity 13 is an impurity associated with dacomitinib.

Dacomitinib impurity 11 is an impurity of Dacomitinib.

Dacomitinib impurity 12 is an impurity of Dacomitinib.

Dacomitinib impurity 1 is an impurity associated with Dacomitinib.

Dacomitinib Impurity 14 is a byproduct associated with Dacomitinib.

Dacomitinib-[D10] Dihydrochloride Salt (Standard) is a reference standard of Dacomitinib-[D10] Dihydrochloride Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Dacomitinib Intermediate 2 (N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine) has anticancer activity and can be used to study lung cancer.