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dacomitinib

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    4
    TargetMol | Inhibitors_Agonists
Dacomitinib
PF-299804, PF-00299804, PF299
T24831110813-31-4
Dacomitinib (PF299)(PF299804; PF-00299804) is a highly selective, orally bioavailable small-molecule inhibitor of the HER family of tyrosine kinases with IC50 of 6, 45.7 and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
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Dacomitinib hydrate
PF 299804, PF00299804, PF 00299804, PF-00299804, PF299804, PF-299804
T199651042385-75-0
Dacomitinib hydrate (PF 299804) is a highly selective and second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor family of tyrosine kinases. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells.
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Dacomitinib metabolite M2
UNII-SOA52D3NLL, Dacomitinib cysteine conjugate
T239501262034-38-7
Dacomitinib metabolite M2 is also known as Dacomitinib cysteine conjugate. Dacomitinib inhibits both the wild-type (WT) EGFR and EGFR T790M.
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3-6 months
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Dacomitinib Intermediate 2
N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine
T67152179552-74-0
Dacomitinib Intermediate 2 (N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine) has anticancer activity and can be used to study lung cancer.
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7-10 days
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