dabigatran etexilate

Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor that binds to thrombin, blocking its thrombogenic activity and preventing thrombus formation.

Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).

N-Nitroso-dabigatran etexilate-13C6 (Dabigatran impurity 95-13C6) is a 13C-labeled version of N-Nitroso-dabigatran etexilate.

Dabigatran Etexilate-[13C6] (Standard) is a reference standard of Dabigatran Etexilate-[13C6] intended for quantitative analysis, quality control, and related biochemical research applications.

BIBR 1087 SE (Desethyl Dabigatran Etexilate) is a metabolite of dabigatran etexilate.

Dabigatran acyl-β-D-glucuronide is a major active metabolite of the thrombin inhibitor dabigatran . The prodrug of dabigatran, dabigatran etexilate , is hydrolyzed by plasma esterases to form dabigatran, which is metabolized primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT2B15 to form dabigatran acyl-β-D-glucuronide. Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma equipotently to dabigatran.