d18:1/18:0

C18 D-threoCeramide (d18:1/18:0) is a synthetic ceramide and stereoisomer of C18 ceramide .1It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50value of 16.6 μM.2[Matreya, LLC. Catalog No. 1855] 1.Koolath, S., Murai, Y., Suga, Y., et al.Chiral combinatorial preparation and biological evaluation of unique ceramides for inhibition of sphingomyelin synthaseChirality32(3)308-313(2019) 2.Usta, J., El Bawab, S., Roddy, P., et al.Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidaseBiochemistry40(32)9657-9668(2001)

C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 0.21 mol% (16.8 μM).

C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. Levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. It is increased in brain from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale. It is also increased in plasma from patients with metachromatic leukodystrophy (MLD).

C18 Sphingomyelin (d18:1/18:0) is a lipid molecule that can be used in life science related research. The CAS number of C18 Sphingomyelin (d18:1/18:0) is 54336-69-5.

GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a sphingolipid with potential applications in research on Parkinson's disease and Lewy body dementia.

C18 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from lactosylceramide . It inhibits aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate (PMA; 10008014) when used at a concentration of 1 μM. C18 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. C18 globotriaosylceramide also accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease.

C18 L-erythro Ceramide (d18:1/18:0) significantly reduced extracellular Aβ levels and can be used to study Alzheimer's disease.

C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin, promoting the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (HUVECs) at concentrations of 0.5 to 5 µM. It exhibits elevated levels in CFPAC-1 pancreatic ductal adenocarcinoma cells compared to pancreatic cancer stem cells, and its myocardial concentration is heightened in Langendorff isolated perfused mouse hearts under an ex vivo ischemia model.

C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is a lipid molecule that can be used in life science related research. The CAS number of C18 ((±)-2'-hydroxy) Ceramide (d18:1/18:0) is 34249-41-7.

Ganglioside GM1, a monosialylated ganglioside and the prototypical ganglioside, contains a single sialic acid residue. C18 Ganglioside GM1 is predominantly located in the brain, especially in the piriform cortex, amygdala nucleus, striatum, and hippocampal CA1 region. The C18 ganglioside GM1 (d20:1/18:0) to (d18:1/18:0) ratio is reduced in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease patients' postmortem tissue. Since this product is naturally sourced, variations in the sphingoid backbone may occur. [Matreya, LLC.]

C18:0 GM2(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GM3(Neu5Gc) Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GD2 Ceramide (d18:1/18:0) is a type of ganglioside.

C18:0 Lc4 Ceramide (d18:1/18:0) is a ganglioside.

C18:0 GM1(Neu5Gc) Ceramide (d18:1/18:0) is classified as a ganglioside.

C18:0 B Antigen ceramide (d18:1/18:0) is a type of ganglioside.

C18:0 Lc3 Ceramide (d18:1/18:0) is a ganglioside.

C18:0 Fuc-GM1 Ceramide (d18:1/18:0) is a ganglioside useful in the synthesis of lipid nanoparticles for drug delivery.

C18:0 GB4 Ceramide (d18:1/18:0) is a type of sphingolipid.

C18:0 GT1b (d18:1/18:0) (triammonium) is a type of glycosphingolipid.

C18:0 GD1a (d18:1/18:0) diammonium is a type of glycosphingolipid.

C18 3'-sulfo Lactosylceramide (d18:1/18:0) is a sphingolipid containing a sulfonic acid group.

EOS (d18:1/30:0/18:2) is a lipid molecule that can be used in life science related research. The CAS number of EOS (d18:1/30:0/18:2) is 97040-38-5.

C6 Biotin Glucosylceramide (d18:1/6:0) is a lipid molecule that can be used in life science related research. The CAS number of C6 Biotin Glucosylceramide (d18:1/6:0) is 2692623-22-4.