d-xylulose

D-Xylulose is converted from xylitol by the enzyme NAD+-linked xylitol dehydrogenase in the glucuronate pathway, the most important xylitol-handling metabolic pathway in mammals.

DXR inhibitor 11a, with an IC50 value of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum's growth in isolated human erythrocytes, with an IC50 of 0.37 µM.

Antibacterial agent 242, a potent inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), demonstrates an IC50 of 5.46 μM against Toxoplasma gondii. It effectively inhibits the enzymatic activity of TgDXR in vitro as well as the proliferation of T. gondii.

D-PheTrAP is a bisubstrate analog inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase (DXPS). It inhibits Escherichia coli DXPS (EcDXPS) and Pseudomonas aeruginosa DXPS (PaDXPS) with IC50 values of 0.52 μM, 2.1 μM, 2.4 μM, and 1.7 μM for wild-type (WT) EcDXPS, EcA426E, WT PaDXPS, and PaE431A, respectively.

DXR-IN-4 (Compound 12a) is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). It effectively inhibits DXR in Plasmodium falciparum, Escherichia coli, and Mycobacterium tuberculosis, with IC50 values for PfDXR, EcDXR, and MtDXR at 18, 4.9, and 89 nM, respectively. Additionally, DXR-IN-4 demonstrates antimalarial activity against Plasmodium falciparum strains 3D7 and Dd2, with IC50 values of 11 μM and 12 μM.

FR900098 is an antimalarial agent that inhibits 1-deoxy-D-xylulose-5-phosphate (DXP) reductoisomerase. It exhibits no significant acute toxicity or genotoxicity and does not have the capability to cause chromosomal breaks or heterogeneity. Additionally, FR900098 has no impact on the bone marrow erythrocytes of NMRI mice.

DXR-IN-1 (Compound 13E) is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). It exhibits high selectivity for DXR of Plasmodium falciparum with an IC50 of 0.030 μM. DXR-IN-1 impedes the growth of Plasmodium by binding to the active site of DXR and inhibiting its catalytic activity.

DXPS-IN-1 (Compound 8) is an inhibitor of 1-deoxy-D-xylulose-5-phosphate synthase (DXPS), exhibiting a Ki value of 2.9 nM against EcDXPS. It also possesses antibacterial properties.

Antimalarial agent 27 (compound 11a) potently inhibits P. falciparum with an IC50 of 0.37 μM, targeting the parasite's 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme with an IC50 of 0.11 μM, indicating its mechanism of action [1].

DXR inhibitor 11a, with an IC50 of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also hampers the growth of P. falciparum in isolated human erythrocytes, demonstrating an IC50 of 0.37 µM.

Anti-infective agent 9 (compound 1) acts as a Plasmodium falciparum inhibitor, demonstrating an IC 50 of 600 nM. It effectively reduces pyruvate levels and disrupts the TCA cycle within Plasmodium. This compound also exhibits robust metabolic stability and minimal toxicity to human liver cells. Research indicates that the potential targets of Anti-infective agent 9 for inhibiting Plasmodium falciparum do not include 1-deoxy-D-xylulose-5-phosphate synthase (DXPS) [1].

Xylose-4-13C is the 13C-labeled form of Xylose. D-(+)-Xylose is a natural compound that, when catalyzed by xylose isomerase, converts to xylulose, a crucial step in the anaerobic fermentation of xylose.

Xylose-1-13C is a 13C-labeled form of Xylose. D-(+)-Xylose is a natural compound that, under the catalysis of xylose isomerase, is converted into xylulose, a crucial step in the anaerobic fermentation of xylose to ethanol.

Xylose-5-13C is a 13C-labeled form of xylose. D-(+)-(Xylose) is a natural compound that, when catalyzed by xylose isomerase, forms xylulose, a crucial step in the anaerobic ethanol fermentation of xylose.

Xylose-2-13C is a form of xylose labeled with carbon-13. D-(+)-xylose (Xylose) is a naturally occurring compound that, through the catalysis of xylose isomerase, is converted to xylulose, which is an essential step in the anaerobic ethanol fermentation of xylose.

1-Deoxy-D-threo-pentulose is a derivative of D-xylulose with active applications in the study of the mevalonate pathway. This compound is extensively used to explore cellular metabolic mechanisms and holds significant experimental value in biochemical research.