curcumin-d-6

Curcumin-D6 is deuterium-labeled curcumin (Turmeric yellow). Curcumin (T1516) (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-angiogenic activities. Curcumin (T1516) is an inhibitor of p300 histone acetyltransferases (HATs), and also shows inhibitory effects on NF-κB and MAPKs.

Tetrahydrocurcumin-D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin (T3735) displays inhibitory activity for CYP2C9 and CYP3A4.

PDMP hydrochloride is a ceramide analog originally developed as an inhibitor of glucosylceramide synthase that contains four stereoisomers due to two adjacent chiral centers, and while total PDMP hydrochloride inhibits glucosylceramide synthase by approximately 90% at 0.8 μM in MDCK cell homogenates, the inhibitory activity resides in the D-threo (1R,2R) enantiomer, which also blocks β-1,4-galactosyltransferase 6, prevents lactosylceramide-driven neuroinflammation in experimental autoimmune encephalomyelitis, additionally, PDMP hydrochloride enhances curcumin-induced antiproliferative and pro-apoptotic effects in melanoma cells.