csf1rin1

CSF1R-IN-1 is a CSF1R inhibitor with an IC50 of 0.5 nM.

CSF1R-IN-18 (Compound 16t) is an aniline derivative that acts as an inhibitor of the colony stimulating factor 1 receptor (CSF1R). It is applicable in research related to cancer, central nervous system disorders, and bone diseases.

CSF1R-IN-13 is a powerful CSF1R inhibitor with potential applications in researching cancer diseases [1]. CSF1R, also known as colony stimulating factor 1 receptor, is a critical growth factor that regulates various cell types, including bone marrow progenitor cells, monocytes, macrophages, and giants [1]. CSF1R-IN-13 shows promise in furthering our understanding of cancer-related disorders (WO2019134661A1, compound 32) [1].

CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.

CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor with an IC50 of 0.005 μM.

CSF1R-IN-14, an isoindolinone derivative compound, is a potent inhibitor of CSF1R. CSF1R-IN-14 has potential for cancer disease research.

Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.

CSF1R-IN-17 (compound 9) is a potent and selective antagonist of CSF1R with an IC50 of 0.2 nM, capable of inhibiting osteoclast differentiation [1].

CSF1R-IN-15 (compound 23) serves as an inhibitor of the colony-stimulating factor-1 receptor (CSF1R), a tyrosine kinase located in the macrophage cell membrane. This receptor is activated by colony-stimulating factor-1 (CSF-1) and interleukin-34. Signaling through CSF1R is essential for the differentiation, proliferation, and survival of macrophages [1].

CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].