cne-2z

LY294002 (SF 1101) is a broad-spectrum inhibitor of PI3K, inhibiting PI3Kα, PI3Kδ, and PI3Kβ (IC50=0.5/0.57/0.97 μM). LY294002 is also an inhibitor of DNA-PK (IC50=1.4 μM) and an inhibitor of CK2 (IC50=98 nM). LY294002 activates apoptosis and autophagy.

LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation.

Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1 and decreases STK38 kinase activity. Tanespimycin also downregulated stk38 gene expression.

Cinobufaginol is a natural bufadienolide isolated from the secretions of the Chinese toad (Bufo bufo gargarizans). Cinobufaginol exhibits significant cytotoxicity against various tumor cell lines, with IC₅₀ values of 803 μM and 1.270 μM for the human nasopharyngeal carcinoma cell lines CNE-1 and CNE-2Z, respectively. In tests against various cancer cell lines, including A549 (lung cancer), HCT-116 (colon cancer), and SKOV3 (ovarian cancer), the IC₅₀ values for cinobufaginol were all below 2.17 μM.