cmpda

CMPDA is a positive allosteric modulator of AMPA receptors [EC50s: 45.4 nM/63.4 nM for GluA2i/GluA2o receptor].

MS 347a is a myosin light chain kinase (MLCK) inhibitor; an epoxide analog of sydowinin B (MS-347b).

Cmpd-A is a time-dependent inhibitor of Centromere-associated protein E (CENP-E). It inhibits ATPase activity and exhibits an ATP-competitive-like behavior. In cellular models, Cmpd-A causes chromosome misalignment and leads to mitotic arrest, thereby inhibiting tumor cell proliferation.

BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2].