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Search Results for " clotting "

Targets

15

Compounds

5

Natural Products

16

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T1736 Apixaban BMS-562247-01 Factor Xa
Apixaban (BMS-562247-01) is an orally active inhibitor of coagulation factor Xa with anticoagulant activity. Apixaban directly inhibits factor Xa, thereby interfering with the conversion of prothrombin to thrombin and pr...
T19786 Hematin Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid Others
Hematin (Ferrihemic acid) is an iron-containing porphyrin. It is used for testing in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
T9999 Sirtuin modulator 2 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide Others , Sirtuin
Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.
T5519 Bivalirudin BG-8967,Hirulog-1 Thrombin
Bivalirudin (BG-8967) is a reversible inhibitor of α- and ζ-thrombin (Kis = 2.56 and 1.84 nM, respectively), enzymes that exhibit high fibrinogen-clotting activities.
T31206 Darexaban YM 150,Darexaban, Tanexaban,YM150 Factor Xa
Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formati...
T23898 Clocoumarol Clocoumarolum,BRN 1264788,DB 112
Clocoumarol is an anticoagulant that prevents blood clotting. It also can inhibit the dilatation of the spleen and the congestion of lymph nodes.
T26702 AZ12971554 AZ 12971554,AZ-12971554
AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68µM, Ecarin clotting time (ECT) IC50 = 0.16µM in human plasma.
T41029 Streptokinase
Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary ar...
T14682 BMS-962212 Others
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated p...
TP1129 Boc-Ile-Glu-Gly-Arg-AMC IEGR-AMC
Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC), a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa). Boc-IEGR-AMC is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi.
T28491 R-1663 R1663
R-1663 is a factor Xa inhibitor. R-1663 prolonged clotting times, inhibited thrombin generation (peak height and endogenous thrombin potential [ETP]) and anti-factor Xa activity in a concentration-dependent manner withou...
T75152 ARC19499
ARC19499, an aptamer, inhibits the tissue factor pathway inhibitor (TFPI), facilitating clot initiation and propagation through the extrinsic pathway. It binds specifically to TFPI, blocking its inhibition of both factor...
T83717 Cys-Pexiganan TFA
Cys-pexiganan, a derivative of pexiganan with an added N-terminal cysteine, is an antimicrobial peptide effective against P. aeruginosa and S. aureus, with minimum inhibitory concentrations (MICs) of 64 and 16 µg/ml, res...
T26657 AR-H067637
AR-H067637 is a rapid-binding, reversible and potent (inhibition constant K(i) = 2-4 nM), competitive inhibitor of thrombin, as well as of thrombin bound to fibrin (clot-bound thrombin) or to thrombomodulin. The total am...
T74672 Sirtuin modulator 5
Sirtuin Modulator 5, a sirtuin modulating agent, activates SIRT1 with an efficacy marked by a DC50 value of less than 50 μM. It is applicable in enhancing cell longevity and is researched for its therapeutic potential in...
Cat No. Product Name Synonyms Targets
T1607 Hydrastinine hydrochloride Others
Hydrastinine hydrochloride is a semisynthetic alkaloid from the hydrolysis of the alkaloid Hydrastine, used as a haemostatic drug.
T5742 Isodemethylwedelolactone Isodemethylwedelolacton Others
Isodemethylwedelolactone (Isodemethylwedelolacton) is a natual product,has Clotting activity.
T0465 Ellagic acid Gallogen,Elagostasine Hedgehog/Smoothened , Casein Kinase , Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , PKA , Syk , PKC , Carbonic Anhydrase
Ellagic acid (Gallogen) is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used...
T0809 Dicoumarol Dicumarol Dehydrogenase , NADPH , PDK
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol is a competitive inhibitor of vitamin K epoxidereductase; t...
T21296 Desmopressin acetate trihydrate Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine
Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clottin...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-03618 Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) Tachypleus tridentatus E. coli
Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc) is expressed in E. coli.
TMPH-00346 Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His) Carcinoscorpius rotundicauda E. coli
This enzyme is closely associated with an endotoxin-sensitive hemolymph coagulation system which may play important roles in both hemostasis and host defense mechanisms. Its active form catalyzes the activation of factor...
TMPY-02530 Tissue Factor Protein, Human, Recombinant (His) Human HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-05094 Tissue Factor Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-01101 Coagulation factor X/F10 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the...
TMPK-00204 FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated Human HEK293
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which al...
TMPJ-00502 Serpin G1 Protein, Human, Recombinant (His) Human Human Cells
As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein...
TMPY-06957 Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02537 Tissue Factor Protein, Human, Recombinant (hFc) Human HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-01325 Tissue Factor Protein, Mouse, Recombinant (His) Mouse HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-02318 Tissue Factor Protein, Rabbit, Recombinant (His) Rabbit HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-03209 Tissue Factor Protein, Rat, Recombinant (His) Rat HEK293
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPY-05083 Tissue Factor Protein, Human, Recombinant (aa 1-295, His) Human Baculovirus-Insect Cells
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemost...
TMPJ-00301 Coagulation Factor X Protein, Human, Recombinant (hFc) Human Human Cells
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways a...
TMPJ-00707 Coagulation factor X/F10 Protein, Mouse, Recombinant (His) Mouse Human Cells
Mouse coagulation factor X / F10 a member of the peptidase S1 family. The mature F10 is composed mostly of two EGF-like domains, one Gla gamma-carboxy-glutamate domain and one peptidase S1 domain. Factor Xa is a vitamin ...
TMPJ-00734 KNG1 Protein, Human, Recombinant (His) Human Human Cells
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ...
Clotting factor C Protein, Tachypleus tridentatus, Recombinant (His & Myc)
TMPH-03618
Species: Tachypleus tridentatus
Expression System: E. coli
Limulus clotting factor C Protein, Carcinoscorpius rotundicauda, Recombinant (His)
TMPH-00346
Species: Carcinoscorpius rotundicauda
Expression System: E. coli
Tissue Factor Protein, Human, Recombinant (His)
TMPY-02530
Species: Human
Expression System: HEK293
Tissue Factor Protein, Cynomolgus, Recombinant (His)
TMPY-05094
Species: Cynomolgus
Expression System: HEK293
Coagulation factor X/F10 Protein, Human, Recombinant (His)
TMPY-01101
Species: Human
Expression System: Baculovirus-Insect Cells
FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
TMPK-00204
Species: Human
Expression System: HEK293
Serpin G1 Protein, Human, Recombinant (His)
TMPJ-00502
Species: Human
Expression System: Human Cells
Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPY-06957
Species: Human
Expression System: HEK293
Tissue Factor Protein, Human, Recombinant (hFc)
TMPY-02537
Species: Human
Expression System: HEK293
Tissue Factor Protein, Mouse, Recombinant (His)
TMPY-01325
Species: Mouse
Expression System: HEK293
Tissue Factor Protein, Rabbit, Recombinant (His)
TMPY-02318
Species: Rabbit
Expression System: HEK293
Tissue Factor Protein, Rat, Recombinant (His)
TMPY-03209
Species: Rat
Expression System: HEK293
Tissue Factor Protein, Human, Recombinant (aa 1-295, His)
TMPY-05083
Species: Human
Expression System: Baculovirus-Insect Cells
Coagulation Factor X Protein, Human, Recombinant (hFc)
TMPJ-00301
Species: Human
Expression System: Human Cells
Coagulation factor X/F10 Protein, Mouse, Recombinant (His)
TMPJ-00707
Species: Mouse
Expression System: Human Cells
KNG1 Protein, Human, Recombinant (His)
TMPJ-00734
Species: Human
Expression System: Human Cells
Cat No. Product Name
L7500 Coagulation and Anticoagulation Compound Library

154 compounds
A unique collection of 154 procoagulation and anticoagulation related compounds for high throughput screening (HTS) and high content screening (HCS);
L6140 Saccharide and Glycoside Natural Product Library

364 compounds
A unique collection of 364 saccharides and glycosides compounds can be used for HTS and HCS;
TargetMol