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By Target- Antibacterial
- Antibiotic(1)
- Autophagy(1)
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Results for "
cilastatin sodium
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Cilastatin sodiumMK-0791 sodium, MK0791 sodium, CilastatinumT2583L81129-83-1Cilastatin (MK-0791) is a potent, reversible, competitive inhibitor of renal dehydropeptidase I (DHP-I), exhibiting an IC₅₀ of 0.1 μM. By inhibiting DHP-I in the kidney, Cilastatin prevents the enzymatic degradation of β-lactam antibiotics, thereby enhancing their stability and therapeutic efficacy. In addition, Cilastatin demonstrates inhibitory activity against the bacterial metallo-β-lactamase enzyme CphA, with an IC₅₀ of 178 μM. Clinically and experimentally, Cilastatin is widely used as an antibacterial adjunct to improve antibiotic performance and reduce renal metabolism of co-administered β-lactam drugs.
- $31
SizeQTY - IMipenem and cilastatin sodiumT21295985960-17-4Imipenem and cilastatin sodium is a broad-spectrum carbapenem antibiotic combination with the antibacterial activity of β-lactam drugs.
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