chemoprevention

Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.

4′-Bromoflavone is a highly effective inducer of phase II detoxification enzymes and has been identified as a potent agent in cancer chemoprevention.

DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to serve as a chemoprevention drug for patients with metastatic melanoma.

Benzo[a]pyrene (3,4-Benzopyrene) exhibits lung carcinogenicity in animal models and is commonly used for lung cancer modeling and chemoprevention research.

Benzo[a]pyrene (Standard) is the standard substance of Benzo[a]pyrene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Benzo[a]pyrene (3,4-Benzopyrene) exhibits lung carcinogenicity in animal models and is commonly used for lung cancer modeling and chemoprevention research.

Cimigenol is a potential antitumor compound, combination of it with an autophagy inhibitor may be a valuable strategy for the chemoprevention or treatment of colon cancer. It exerted potent cytotoxic activity against SMMC-7721 (7.87μM) and A-549 (12.16 μM

Xanthohumol and xanthohumol D are potent inducers of quinone reductase, suggests that they could be used as chemoprevention agents.

Glyurallin A possesses an antigenotoxic effect against carcinogenic N-methyl-N-nitrosourea (MNU) for the first time, it is important to prevent DNA damage by N-nitrosamines for cancer chemoprevention.

Chamaejasmine could be a candidate drug for osteosarcoma and breast cancer chemoprevention, induces apoptosis in MG63 and HEp-2 cells by Akt inactivation and dephosphorylation of BAD. It inhibits Bcl-2 expression and induces Bax expression to desintegrate