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Results for "
cerulenin
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
Cerulenin
TQ026017397-89-6
Cerulenin is a natural inhibitor of fatty acid synthase (FAS). It is produced by the fungus Cephalosporium caeruleus.
- $92
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Octyl Orlistat
N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, L-Leucine, N-formyl-, (1S)-1-[[(2S,3S)-3-octyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, [(2S)-1-[(2S,3S)-3-octyl-4-oxooxetan-2-yl]tridecan-2-yl](2S)-2-formamido-4-methylpentanoate
T2023991243011-56-4
Octyl Orlistat, a potential fatty acid synthase (FASN) inhibitor, has demonstrated significant effectiveness in reducing tumor cell proliferation. By targeting FASN and inducing apoptosis, Orlistat is under investigation as an anti-tumor compound. Compared to Cerulenin and C75, Orlistat shows greater inhibitory potency in cell culture and cell lines. In LN229 cells, treatment with 200 µM Orlistat for 48 hours resulted in a 63.9 ± 8.7% reduction in cell growth, while in LT68 cells, the reduction was 76.3 ± 23.7%. Organotypic slice cultures treated with Orlistat exhibited decreased proliferation after Ki67 staining and an increase in caspase-3 cleavage.
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